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Ralph Carmel, one of the leading researchers on vitamin B12, published a study in 1988 with several subjects analyzed, suggesting a relationship between higher amounts of accumulated analogues and a greater risk of neurological symptoms, which could explain why some patients did not experience neurological symptoms (at least at the time) but did experience anemia

Disclosure of interest: Nothing to disclose Poster session I - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.01 - DIAGNOSIS/INVESTIGATION OF STROKE ETIOLOGY P355 - ESOC25-189 VESSEL WALL ENHANCEMENT IN TERMINAL OF INTERNAL CAROTID ARTERY WAS DECREASED AFTER DIRECT BYPASS SURGERY FOR MOYAMOYA DISEASE Daizo Ishii 1 , Takeshi Hara 1 , Masashi Kuwabara 1 , Hiroshi Kondo 1 , Shinji Kume 2 , Nobutaka Horie 1 1 Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, 2 Hiroshima University Hospital, Hiroshima, Japan Background and Aims: Intracranial vessel wall enhancement (VWE) on MR imaging is associated with progression and poor outcome in moyamoya disease (MMD)

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